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Products Details
Product Description
– NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].
Web ID
– HY-147506
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H26N4O3S
References
– [1]Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089.
CAS Number
– 2411441-54-6
Molecular Weight
– 474.57
SMILES
– O=C(NC1=CC2=C(CCC2)C=C1)CN3C4=CC=CC=C4N=C3CCNS(=O)(C5=CC=CC=C5)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NOD-like Receptor (NLR)
Isoform
– NOD2
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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