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Products Details
Product Description
– NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB). NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma)[1].
Web ID
– HY-143877
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H16F4N2O4S
References
– [1]Nawar N, Bukhari S, Adile AA, et al. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma. J Med Chem. 2022;65(4):3193-3217.
CAS Number
– 2490284-25-6
Molecular Weight
– 420.38
SMILES
– O=C(NO)C1=CC=C(CN(C(C)C)S(=O)(C2=CC(F)=C(F)C(F)=C2F)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC
Isoform
– HDAC1;HDAC11;HDAC2;HDAC3;HDAC6;HDAC8
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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