NLRP3-IN-9
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NLRP3-IN-9

SKU T28178-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 56 CAD through 1,086 CAD

Products Details

Product Description

– NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.

Web ID

– T28178

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C12H13ClO3

Citations

– 1. Hu Q, Chen Y, Zhang W, et al.Dehydroevodiamine targeting IKKβ to alleviate acute gastric injury via inhibiting the p65/NLRP3 axis.Phytomedicine.2024: 155963.

References

– Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, Marini E, Fantozzi R, Miglio G, Bertinaria M. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82. doi: 10.1021/jm501072b. Epub 2014 Dec 4. PubMed PMID: 25418070.

CAS Number

– 88039-46-7

Molecular Weight

– C12H13ClO3

Compound Purity

– 0.9851

SMILES

– CCOC(=O)C(=C)C(O)c1ccccc1Cl

Pathway

– Immunology/Inflammation|||NF-κB

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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