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Nitroxoline
$25 – $40
Products Details
Product Description
– Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].
Web ID
– HY-B1159
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C9H6N2O3
References
– [1]Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr;35(4):202-208. |[2]A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov;56(11):6021-5.
CAS Number
– 4008-48-4
Molecular Weight
– 190.16
Compound Purity
– 99.57
SMILES
– OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Antibiotic;Apoptosis;Autophagy;Bacterial
Pathway
– Anti-infection;Apoptosis;Autophagy
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
