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Products Details
Product Description
– Nicotinamide riboside, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
Web ID
– HY-123033
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C11H15N2O5
Citations
– Cell Biosci. 2021 Nov 10;11(1):192.|Cells. 2023 Oct 2, 12(19), 2396.|Commun Biol. 2023 Mar 2;6(1):235.|FASEB J. 2022 Jul;36(7):e22418.|Mol Ther. 2022 Sep 21;S1525-0016(22)00567-6.|Redox Biol. 2022 Oct 11;57:102507.|Nat Commun. 2023 Jan 16;14(1):240.
References
– [1]Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.|[2]Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer’s Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8.|[3]Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.
CAS Number
– 1341-23-7
Molecular Weight
– 255.25
SMILES
– NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O
Clinical Information
– Phase 4
Research Area
– Metabolic Disease; Neurological Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Sirtuin
Isoform
– Human Endogenous Metabolite;SIRT1;SIRT3
Pathway
– Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
