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Product Description
– Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
Web ID
– HY-B0341S
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C8H5D4N3O4
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25.|[3]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9.|[4]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65(5):1198-207.
CAS Number
– 1132681-23-2
Molecular Weight
– 215.20
SMILES
– C(NCCON(=O)=O)(=O)C=1C(=C(C(=NC1[2H])[2H])[2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Isotope-Labeled Compounds;Potassium Channel
Pathway
– Membrane Transporter/Ion Channel;Others
Product type
– Isotope-Labeled Compounds
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