Download Files:
NGB 2904
$52 – $600
Products Details
Product Description
– NGB 2904 is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. NGB 2904 shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 antagonizes Quinpirole-stimulated mitogenesis[1][2].
Web ID
– HY-12697
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C28H29Cl2N3O
References
– [1]Xi ZX, et al. The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine’s rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology. 2006;31(7):1393-1405.|[2]Yuan J, et, al. NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8.|[3]Pritchard LM, et, al. The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol Biochem Behav. 2007 Apr;86(4):718-26.
CAS Number
– 189060-98-8
Molecular Weight
– 494.46
Compound Purity
– 99.08
SMILES
– O=C(C1=CC(CC2=C3C=CC=C2)=C3C=C1)NCCCCN4CCN(C5=CC=CC(Cl)=C5Cl)CC4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– Ethanol : 4.55 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Dopamine Receptor
Isoform
– D3 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
