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Nec-3a
Products Details
Product Description
– Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
Web ID
– HY-18899
Shipping
– Room temperature
Molecular Formula
– C21H18F4N2O4
References
– [1]Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.
CAS Number
– 1504558-72-8
Molecular Weight
– 438.37
SMILES
– COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– RIP kinase
Isoform
– RIPK1
Pathway
– Apoptosis
Product type
– Reference compound
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