Products Details

Product Description

– Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

Web ID

– HY-18899

Shipping

– Room temperature

Molecular Formula

– C21H18F4N2O4

References

– [1]Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.

CAS Number

– 1504558-72-8

Molecular Weight

– 438.37

SMILES

– COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– RIP kinase

Isoform

– RIPK1

Pathway

– Apoptosis

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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