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Naphazoline (hydrochloride)
$50 – $96
Products Details
Product Description
– Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research[1][2].
Web ID
– HY-B0446
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H15ClN2
References
– [1]Yamaguchi I, et, al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31.|[2]Quan L, et, al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25.
CAS Number
– 550-99-2
Molecular Weight
– 246.74
Compound Purity
– 98.37
SMILES
– C1(CC2=NCCN2)=CC=CC3=CC=CC=C13.Cl
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Cardiovascular Disease
Solubility
– DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)
Target
– Adrenergic Receptor;Interleukin Related;TNF Receptor;VEGFR
Isoform
– CD40;IL-1;IL-4;IL-6
Pathway
– Apoptosis;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
