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Products Details
Product Description
– Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].
Web ID
– HY-147795
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C36H35N3O4
References
– [1]Zhang K, et al. Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer. J Med Chem. 2022 Jun 9;65(11):7746-7769.
CAS Number
– 2453183-75-8
Molecular Weight
– 573.68
SMILES
– O=C1C2=C(CCCC3(C)C)C3=CC=C2C4=C(C1=O)C(C)=C(O4)CNC5=CC=C(C=C5)CCNC(/C=C/C6=CN=CC=C6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;NAMPT;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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