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Nafamostat (mesylate)
$32 – $110
Products Details
Product Description
– Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat mesylate supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat mesylate blocks activation of SARS-CoV-2.[1][2][3][4].
Web ID
– HY-B0190A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C21H25N5O8S2
Citations
– Antiviral Res. 2023 Apr 17;105606.|Cell Res. 2020 Mar;30(3):269-271.|Eur J Pharmacol. 2022 Feb 2;174795.|Eur J Pharmacol. 2022 Nov 17;175394.|Nat Chem Biol. 2022 Jun 8.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Viruses. 2022, 14(9), 2017.|Biomolecules. 2022, 12(8), 1063.|Cells. 2022, 11(3), 319.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Patent. US20230210807A1.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.
References
– [1]Markus Hoffmann, et al. Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19. Antimicrob Agents Chemother. 2020 Jun; 64(6): e00754-20.|[2]Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.|[3]Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.|[4]Homma S, et al. Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells. Int Immunopharmacol. 2018 Jan;54:39-45.
CAS Number
– 82956-11-4
Molecular Weight
– 539.58
Compound Purity
– 99.97
SMILES
– CS(=O)(O)=O.O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3.CS(=O)(O)=O
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)
Target
– Apoptosis;SARS-CoV;Ser/Thr Protease
Pathway
– Anti-infection;Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
