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Product Description
– Nafamostat hydrochloride, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat hydrochloride supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat hydrochloride blocks activation of SARS-CoV-2.[1][2][3][4].
Web ID
– HY-B0190B
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C19H19Cl2N5O2
Citations
– Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Antiviral Res. 2023 Apr 17;105606.|Cell Res. 2020 Mar;30(3):269-271.|Eur J Pharmacol. 2022 Feb 2;174795.|Eur J Pharmacol. 2022 Nov 17;175394.|Nat Chem Biol. 2022 Jun 8.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Viruses. 2022, 14(9), 2017.|Biomolecules. 2022, 12(8), 1063.|Cells. 2022, 11(3), 319.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|Patent. US20230210807A1.
References
– [1]Homma S, et al. Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells. Int Immunopharmacol. 2018 Jan;54:39-45.|[2]Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.|[3]Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.|[4]Markus Hoffmann, et al. Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19. Antimicrob Agents Chemother. 2020 Jun; 64(6): e00754-20.
CAS Number
– 80251-32-7
Molecular Weight
– 420.29
SMILES
– O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3.Cl.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;SARS-CoV;Ser/Thr Protease
Pathway
– Anti-infection;Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
