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N-butyryl-L-Homoserine lactone-d5
$67
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Products Details
Product Description
– N-butyryl-L-Homoserine lactone-d5 is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].
Web ID
– HY-114816S
Shipping
– Room temperature
Molecular Formula
– C8H8D5NO3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1|[3]Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041.|[4]Feng Sun, et al. Advance of the diversity of bacterial quorum sensing and quorum quenching. National Natural Science Foundation of China. Published online 9 October 2018.
CAS Number
– 2701379-46-4
Molecular Weight
– 176.22
SMILES
– O=C(N[C@H]1CCOC1=O)CC([2H])([2H])C([2H])([2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– ADC Linker;Bacterial;Isotope-Labeled Compounds
Pathway
– Antibody-drug Conjugate/ADC Related;Anti-infection;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
