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Products Details
Product Description
– MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC50 s of 0.019, 0.017, 0.020 and 0.044 μM, respectively[1].
Web ID
– HY-155360
Shipping
– Room temperature
Molecular Formula
– C29H33NO9
References
– [1]Xiang-Jing Fu, et al. Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities, European Journal of Medicinal Chemistry, Volume 262, 2023, 115883.
Molecular Weight
– 539.57
SMILES
– O=C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)N(C2=CC(OC)=C(OC)C(OC)=C2)CC3=CC(O)=C(OC)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;YAP
Pathway
– Apoptosis;Stem Cell/Wnt
Product type
– Reference compound
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