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Products Details
Product Description
– MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
Web ID
– HY-120111A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H24ClN5
References
– [1]Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer’s disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.
CAS Number
– 1923773-01-6
Molecular Weight
– 417.93
SMILES
– CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.[H]Cl
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Autophagy;p38 MAPK
Isoform
– p38α
Pathway
– Autophagy;MAPK/ERK Pathway
Product type
– Reference compound
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