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Products Details
Product Description
– MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
Web ID
– HY-120111B
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H29Cl2N5O2
References
– [1]Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer’s disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.
CAS Number
– 1661020-92-3
Molecular Weight
– 490.43
SMILES
– CN1CCN(C2=NN=C(C3=CC=C4C=CC=CC4=C3)C(C5=CC=NC=C5)=C2)CC1.Cl.O.Cl.O
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 20.83 mg/mL (ultrasonic)
Target
– Autophagy;p38 MAPK
Isoform
– p38α
Pathway
– Autophagy;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
