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mTOR inhibitor-11
Products Details
Product Description
– mTOR inhibitor-11 (Compound 9) is a brain-penetrant mTOR inhibitor (IC50: 21 nM for pS6). mTOR inhibitor-11 also inhibits pCHK1 and PDE4D with IC50s of 17.2 and 17.0 μM. mTOR inhibitor-11 can be used for research of CNS disease[1].
Web ID
– HY-154957
Shipping
– Room temperature
Molecular Formula
– C21H26N6O2
References
– [1]Bonazzi S, et al. Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes. J Med Chem. 2023 Jul 13;66(13):9095-9119.
Molecular Weight
– 394.47
SMILES
– C[C@@H]1COCCN1C2=C3N=C(C4=NC=CC=C4)NC3=NC(N5[C@@H](C)COCC5)=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mTOR
Pathway
– PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.