MTK458
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MTK458

SKU T72420-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 51 CAD through 128 CAD

Products Details

Product Description

– MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson’s disease research.

Web ID

– T72420

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H15F3N4

References

– Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease models. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528378.

CAS Number

– 2499962-58-0

Molecular Weight

– C17H15F3N4

Compound Purity

– 0.9836

SMILES

– N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4

Pathway

– PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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