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MRT68921 (dihydrochloride)
$34 – $1,020
Products Details
Product Description
– MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively[1].
Web ID
– HY-100006A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H36Cl2N6O
Citations
– Biochem J. 2019 Mar 12;476(5):875-887.|Cancer Cell. 2021 May 10;39(5):678-693.e11.|J Cell Physiol. 2021 Dec;236(12):8110-8121.|Nature Cancer. 2021 May;2(5):503-514.|Nature. 2022 Oct;610(7931):366-372.|Patent. US20230068698A1.|Sci Rep. 2023 Jul 3;13(1):10752.|Mol Ther Oncolytics. 28 August 2021.|Patent. US20230068698A1.|Research Square Preprint. 2021 Oct.|Research Square Preprint. 2023 May 22.
References
– [1]Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.
CAS Number
– 2080306-21-2
Molecular Weight
– 507.50
Compound Purity
– 99.58
SMILES
– [H]Cl.O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 33.33 mg/mL (ultrasonic)
Target
– ULK
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
