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Product Description
– MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin[1].
Web ID
– HY-145195
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H13ClF2N4O2S
References
– [1]BIGI S, et, al. 3-amino-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of mrgx2. WO2020223255A1.|[2]Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027.
CAS Number
– 2527815-74-1
Molecular Weight
– 434.85
SMILES
– O=S1(N=C(NCC2=NC=CC=C2F)NC3=C(C4=C(Cl)C=CC=C4)C=C(C=C31)F)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Mas-related G-protein-coupled Receptor (MRGPR)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
