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Products Details
Product Description
– MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research[1].
Web ID
– HY-124638
Shipping
– Room temperature
Molecular Formula
– C25H29N9O
References
– [1]Han W, et al. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. J Med Chem. 2016 Apr 14;59(7):3034-45.
CAS Number
– 1889336-59-7
Molecular Weight
– 471.56
SMILES
– O=C(C1=CC(C2=NC(C3=NC4=CC=CC(N5C[C@H](C)NCC5)=C4N3C)=C(N)N=C2)=NC=C1)N(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MNK
Isoform
– MNK1;MNK2
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
