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Products Details
Product Description
– MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].
Web ID
– HY-147745
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C13H8N4O4
References
– [1]Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257.
CAS Number
– 1772-39-0
Molecular Weight
– 284.23
SMILES
– O=[N+](C1=CC=C(C2=NC3=CC=C([N+]([O-])=O)C=C3N2)C=C1)[O-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MMP
Isoform
– MMP-13;MMP-2;MMP-8;MMP-9
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
