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Products Details
Product Description
– MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL). MLKL-IN-6 inhibits cell necrosis. MLKL-IN-6 inhibits MLKL phosphorylation and oligomerization during cell necrosis, inhibits immune cell death, and reduces the expression of adhesion factors. MLKL-IN-6 has low cytotoxicity, and it inhibits hepatic stellate cell activation, reduces liver fibrosis marker levels, and has anti-fibrotic effects[1].
Web ID
– HY-156119
Shipping
– Room temperature
Molecular Formula
– C20H18N4O5
References
– [1]Oh J H, et al. Novel Inhibitor of Mixed-Lineage Kinase Domain-Like Protein: The Antifibrotic Effects of a Necroptosis Antagonist[J]. ACS Pharmacology & Translational Science, 2023.. . .
Molecular Weight
– 394.38
SMILES
– O=C(OC)/C=C/C(N1C)=NC(N(CC#CC2=CC=CC(O)=C2)C(N3C)=O)=C1C3=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Mixed Lineage Kinase;Necroptosis
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
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