Download Files:
ML169
$234
Only 1000 item(s) left in stock.
Products Details
Product Description
– ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].
Web ID
– HY-120576
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C21H17BrFN3O4S
References
– [1]Reid PR, et al. Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. Bioorg Med Chem Lett. 2011 May 1;21(9):2697-701.
CAS Number
– 1222878-02-5
Molecular Weight
– 506.34
SMILES
– O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mAChR
Isoform
– mAChR1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
