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ML132
$450 – $3,350
Products Details
Product Description
– ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 of 34.9 nM. ML132 shows good stability that can be utilized as molecular probes of caspase 1. ML132 can be used for research in the field of anti-cancer and anti-inflammatory[1].
Web ID
– HY-12412
Storage Temperature
– -80°C, protect from light, stored under nitrogen
Shipping
– Dry Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H28ClN5O5
References
– [1]Adriaenssens Y, et al. Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited. Org Biomol Chem. 2017 Sep 13;15(35):7456-7473.
CAS Number
– 1230628-71-3
Molecular Weight
– 477.94
Compound Purity
– 98.75
SMILES
– ClC1=CC(C(N[C@@H](C(C)(C)C)C(N2CCC[C@H]2C(N[C@@H](CC(O)=O)C#N)=O)=O)=O)=CC=C1N
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Caspase
Isoform
– Caspase 1;Caspase 4;Caspase 5;Caspase 8;Caspase 9
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
