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ML 297
$70 – $530
Products Details
Product Description
– ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].
Web ID
– HY-110192
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H14F2N4O
References
– [1]Wen W, et al. Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6.|[2]Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.
CAS Number
– 1443246-62-5
Molecular Weight
– 328.32
Compound Purity
– 98.85
SMILES
– FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
