Download Files:
MK-0557
$168 – $1,920
Products Details
Product Description
– MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
Web ID
– HY-15411
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H19FN4O3
References
– [1]Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2738-43.|[2]Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4(4):275-82.
CAS Number
– 328232-95-7
Molecular Weight
– 406.41
Compound Purity
– 99.84
SMILES
– O=C([C@H]1CC[C@@](C2=C3C=CN=C2)(OC3=O)CC1)NC4=NN(C5=CC=CC=C5F)C=C4
Clinical Information
– Phase 3
Research Area
– Metabolic Disease; Endocrinology
Solubility
– DMSO : 200 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
Target
– Neuropeptide Y Receptor
Isoform
– NPY Y5 receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
