Download Files:
Mirodenafil (dihydrochloride)
$56 – $430
Products Details
Product Description
– Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc)[1][2][3].
Web ID
– HY-14930A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Molecular Formula
– C26H39Cl2N5O5S
References
– [1]Park HJ, et al. Mirodenafil for the treatment of erectile dysfunction: a systematic review of the literature. World J Mens Health. 2014 Apr;32(1):18-27.|[2]Kang BW, et al. Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions. Alzheimers Res Ther. 2022 Jul 8;14(1):92.|[3]Roh JS, et al. Mirodenafil ameliorates skin fibrosis in bleomycin-induced mouse model of systemic sclerosis. Anim Cells Syst (Seoul). 2021 Nov 3;25(6):387-395.
CAS Number
– 862189-96-6
Molecular Weight
– 604.59
Compound Purity
– 99.85
SMILES
– [H]Cl.[H]Cl.O=C1C(N(CC)C=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(CCO)CC4)=O)=CC=C3OCCC)N1
Clinical Information
– Launched
Research Area
– Endocrinology; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;Glucocorticoid Receptor;Phosphodiesterase (PDE);Wnt;β-catenin
Isoform
– PDE5
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
