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Products Details
Product Description
– Minodronic acid-d4 is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].
Web ID
– HY-16322S
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H8D4N2O7P2
References
– [1]Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61.|[2]Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 1807367-80-1
Molecular Weight
– 326.17
SMILES
– O=P(O)(O)C(P(O)(O)=O)(O)CC1=CN=C2N1C([2H])=C([2H])C([2H])=C2[2H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Isotope-Labeled Compounds;P2X Receptor
Isoform
– P2X2 Receptor;P2X3 Receptor
Pathway
– Apoptosis;Membrane Transporter/Ion Channel;Others
Product type
– Isotope-Labeled Compounds
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