MID-1

$95$1,200

Products Details

Product Description

– MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake[1].

Web ID

– HY-115461

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C12H11N3O4S

References

– [1]Lee H, et, al. MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle. J Biol Chem. 2016 Dec 23;291(52):26627-26635.

CAS Number

– 312608-54-1

Molecular Weight

– 293.30

Compound Purity

– 99.36

SMILES

– O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(OCC)C=C2

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease

Solubility

– DMSO : 31.25 mg/mL (ultrasonic)

Target

– Insulin Receptor

Pathway

– Protein Tyrosine Kinase/RTK

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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