MI-883
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MI-883

SKU T205648-10 mg Category Brand:

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Products Details

Product Description

– MI-883 is an orally active Constitutive Androstane Receptor (CAR, EC50=73 nM) agonist and a Pregnane X Receptor (PXR, IC50=0.1 μM) antagonist. It enhances CAR LBD assembly (EC50=0.38 µM) and activates the CAR3 variant (EC50=0.074 µM), inducing CYP2B6 mRNA expression in HepaRG and primary human hepatocytes. Additionally, MI-883 inhibits the basal activity of PXR (IC50=2.03 µM) and reduces CYP3A4 mRNA expression in transiently transfected HepG2 cells. It also regulates cholesterol metabolism and bile acid excretion, improving hypercholesterolemia in mouse models.

Web ID

– T205648

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H15Cl2FN6O

CAS Number

– 2530027-71-3

Molecular Weight

– C23H15Cl2FN6O

SMILES

– O=C(N)C1=CC(=CC=C1Cl)CN2N=NC(=C2)C3=C(N=C4C=C(F)C=CN43)C=5C=CC(Cl)=CC5

Target

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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