Download Files:

Mezigdomide

SKU HY-129395-10 mg Category Reference compound Tags Apoptosis;E1/E2/E3 Enzyme;Molecular Glues, Apoptosis;Metabolic Enzyme/Protease;PROTAC, Cancer

$350 – $2,250

Size10 mg

5 mg 10 mg 50 mg 100 mg

Clear

$550

Only 1000 item(s) left in stock.

Products Details

Product Description

– Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1].

Web ID

– HY-129395

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C32H30FN5O4

References

– [1]Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31.

CAS Number

– 2259648-80-9

Molecular Weight

– 567.61

Compound Purity

– 99.68

SMILES

– N#CC1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@@H](CC6)C(NC6=O)=O)C5=O)C=C3)CC2)C(F)=C1

Clinical Information

– Phase 3

Research Area

– Cancer

Solubility

– DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– Apoptosis;E1/E2/E3 Enzyme;Molecular Glues

Pathway

– Apoptosis;Metabolic Enzyme/Protease;PROTAC

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.