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Products Details
Product Description
– Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].
Web ID
– HY-124824
Shipping
– Room temperature
Molecular Formula
– C16H16O6
References
– [1]Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24(1):44-52. |[2]Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62(3):1609-1625.
CAS Number
– 700870-56-0
Molecular Weight
– 304.29
SMILES
– O=C(OC)C1=C(C)C=C(OC2=CC(C)=CC(O)=C2O)C=C1O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Glyoxalase (GLO)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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