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Methotrexate
Price range: 48 CAD through 317 CAD
Products Details
Product Description
– Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
Web ID
– T1485
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H22N8O5
Citations
– 1. Li X, Xi B, Miao Y, et al. Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling. International Immunopharmacology. 2021, 100: 108129.
2. Zhao Y, Li Y, Zhu R, et al.RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modification.Signal Transduction and Targeted Therapy.2023, 8(1): 224.
3. Kutbi D, Almalki R S.Valsartan Mitigates the Progression of Methotrexate-Induced Acute Kidney Injury in Rats via the Attenuation of Renal Inflammation and Oxidative Stress.Journal of Inflammation Research.2024: 2233-2243.
4. Du J, Zou Q, Shen Y, et al.Monotropein mitigates methotrexate-induced liver injury by activating autophagy and inhibiting ferroptosis.Journal of Functional Foods.2024, 121: 106413.
5. Chen K, Gao Y, Xia N, et al.Long-term therapeutic effects of allogeneic mesenchymal stem cell transplantation for intrauterine adhesions.Stem Cell Research & Therapy.2024, 15(1): 1-13.
References
– Norris RE, et al. Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias. Cancer Chemother Pharmacol. 2010 May;65(6):1125-30.
CAS Number
– 59-05-2
Molecular Weight
– C20H22N8O5
Compound Purity
– 0.9991
SMILES
– NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
Target
– Others
Pathway
– Antibody-drug Conjugate/ADC Related|||Apoptosis|||Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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