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Products Details
Product Description
– Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].
Web ID
– HY-144659
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H16N4O3
References
– [1]Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA. Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases. Eur J Med Chem. 2022 Jan 15;228:113975.
CAS Number
– 1417737-65-5
Molecular Weight
– 348.36
SMILES
– N#CCN(CC1=CC([N+]([O-])=O)=C2C=CC=NC2=C1O)CC3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bacterial
Pathway
– Anti-infection;Apoptosis
Product type
– Reference compound
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