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Melatonin
$30 – $80
Products Details
Product Description
– Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].
Web ID
– HY-B0075
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C13H16N2O2
References
– [1]Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin’s neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665|[2]Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31|[3]Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1|[4]Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.|[5]Zhi Chen, et al. Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res. 2019 May 10;12(1):43.
CAS Number
– 73-31-4
Molecular Weight
– 232.28
Compound Purity
– 99.93
SMILES
– CC(NCCC1=CNC2=C1C=C(OC)C=C2)=O
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 12.5 mg/mL (ultrasonic)|H2O : 1.1 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Endogenous Metabolite;Melatonin Receptor;Mitophagy
Isoform
– Human Endogenous Metabolite;Microbial Metabolite
Pathway
– Apoptosis;Autophagy;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
