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MEK-IN-5
SKU
HY-143468-Get quote
Category Reference compound
Tags Apoptosis;MAPK/ERK Pathway, Apoptosis;MEK, Cancer
Products Details
Product Description
– MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].
Web ID
– HY-143468
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H27FN4O10S2
References
– [1]Wang C, et al. Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs. Eur J Med Chem. 2020; 196:112271.
CAS Number
– 2417022-06-9
Molecular Weight
– 674.67
SMILES
– O=C1OC2=C(C(C)=C1CC3=C(F)C(NS(=O)(NC)=O)=CC=C3)C=CC(OCCCOC4=NO[N+]([O-])=C4S(=O)(C5=CC=CC=C5)=O)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MEK
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.