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Products Details
Product Description
– MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].
Web ID
– HY-143468
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H27FN4O10S2
References
– [1]Wang C, et al. Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs. Eur J Med Chem. 2020; 196:112271.
CAS Number
– 2417022-06-9
Molecular Weight
– 674.67
SMILES
– O=C1OC2=C(C(C)=C1CC3=C(F)C(NS(=O)(NC)=O)=CC=C3)C=CC(OCCCOC4=NO[N+]([O-])=C4S(=O)(C5=CC=CC=C5)=O)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MEK
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
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