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Products Details
Product Description
– Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1][2].
Web ID
– HY-B1834S1
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H25D5O3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.
Molecular Weight
– 347.50
SMILES
– C[C@@]12[C@](C(C([2H])([2H])[2H])=O)(O)CC[C@@]1([H])[C@]3([H])C=C(C)C4=CC(C([2H])([2H])C[C@]4(C)[C@@]3([H])CC2)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite;Isotope-Labeled Compounds
Pathway
– Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
