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Meclofenamic acid
$100
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Products Details
Product Description
– Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].
Web ID
– HY-117275
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H11Cl2NO2
Citations
– Biomed Opt Express. 2021 Mar 9.|Biomater Adv. 2023 Sep 22, 213634.|Sensor Actuat B-Chem. 2021, 129983.|Theranostics. 2021 Jul 25;11(17):8464-8479.
References
– [1]Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.|[2]Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.|[3]Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.|[4]Lee YT, et al. Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol. 1999 Aug 13;378(3):349-56.
CAS Number
– 644-62-2
Molecular Weight
– 296.15
Compound Purity
– 98.0
SMILES
– O=C(O)C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl
Clinical Information
– Launched
Research Area
– Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
– Methanol : 7.14 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Fat Mass and Obesity-associated Protein (FTO);Gap Junction Protein;Potassium Channel
Pathway
– Cytoskeleton;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
