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MCC950 (sodium)
$60 – $320
Products Details
Product Description
– MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
Web ID
– HY-12815A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H23N2NaO5S
Citations
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September 15th, 2022.|Sci Immunol. 2022 Feb 4;7(68):eabk2092.|Sci Total Environ. 2023 Apr 13;163460.|Sci Transl Med. 2023 Jan 11;15(678):eabl7895.|SSRN. 8 Nov 2021.|Ther Adv Med Oncol. 2021 Jan 21.|Toxicology. 2019 Dec 1;428:152304.|Toxics. 2022, 10(6), 285.|Vet Microbiol. 2021, 109130.|Virulence. 2022 Dec;13(1):1486-1501.|ACS Nano. 2023 Nov 21.|Acta Pharmacol Sin. 2021 Aug 2.|Aging Cell. 2023 Mar 31;e13811.|Anat Rec. 2021 Feb;304(2):302-312.|Arch Biochem Biophys. 2023 Mar 4;109558.|Atherosclerosis. 2019 Oct;289:132-142.|Autophagy. 2020 Dec 19;1-16.|Basic Res Cardiol. 2022 Aug 23;117(1):40.|Biochem Biophys Res Commun. 2019 Jun 30;514(3):998-1003.|Biochem Biophys Res Commun. 2020 Apr.|Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Nov 27:159428.|Biochim Biophys Acta Mol Cell Res. 2023 Oct 5:119603.|Biochim Biophys Acta. 2017 Feb 13;1863(6):1556-1567.|Biochim Biophys Acta. 2017 Oct 3;1864(1):1-10.|Biofactors. 2018 Mar;44(2):123-136.|Biomed Pharmacother. 2022 Jun 6;152:113229.|Biomed Pharmacother. 2023 Jan 11;159:114216.|Biomed Pharmacother. 2023 Jun 28;165:115047.|bioRxiv. 2023 Jul 7.|BMC Cardiovasc Disord. 2023 Sep 11;23(1):446.|Cell Commun Signal. 2023 May 25;21(1):123.|Cell Death Dis. 2017 Nov 16;8(11):e3170. |Cell Death Dis. 2020 May 15;11(5):377.|Cell Death Dis. 2023 Mar 17;14(3):200.|Cell Death Discov. 2022 Dec 29;8(1):500.|Cell Mol Immunol. 2020 Mar;17(3):283-299.|Cell Prolif. 2020 Dec 31;e12973.|Chem Biol Interact. 2023 May 9;110541.|Clin Exp Immunol. 2018 Nov;194(2):231-243. |Clin Immunol. 2023 Mar 22;250:109300.|Dig Dis Sci. 2018 Jan;63(1):81-91.|Ecotoxicol Environ Saf. 2022 Dec 9;249:114359.|Eur J Pharmacol. 2022 Nov 3;175364.|Eur J Pharmacol. 2023 Nov 9:176182.|Evid Based Complement Alternat Med. 2018 Aug 26;2018:3571604. |Exp Biol Med. 2023 Sep 25:15353702231191124.|Exp Cell Res. 2019 Oct 1;383(1):111488.|Exp Ther Med. 2023 Feb 15.|Food Chem Toxicol. 2019 Mar;125:392-402.|Food Chem Toxicol. 2023 Jun 2;113870.|Food Chem Toxicol. 2023 Sep 23;114060.|Free Radic Biol Med. 2021 Jul 8;S0891-5849(21)00408-1.|Free Radic Biol Med. 2023 Mar 27;202:46-61.|Front Immunol. 2020 Jul 24;11:1863.|Front Pharmacol. 2020 Mar 31;11:200.|Front Pharmacol. 2022 Jul 5;13:906548.|Front Psychiatry. 2019 Jan 7;9:734.|Immunology. 2022 Apr 25.|Inflammopharmacology. 2020 Dec;28(6):1495-1508.|Int Immunol. 2023 Sep 26:dxad037.|Int Immunopharmacol. 2021 Jan 7;92:107352.|Int Immunopharmacol. 2022 Dec 9;114:109523.|Int Immunopharmacol. 2022 Jul 6;110:109012.|Int Immunopharmacol. 2023 Aug 11;123:110752.|Int Immunopharmacol. 2023 Jul 31;123:110657.|Int J Biol Sci. 2023; 19(3):936-949.|Int J Mol Med. 2018 Aug;42(2):1086-1095.|Int J Mol Med. 2023 Apr;51(4):32.|Int J Mol Sci. 2022, 23(21), 13224.|Int J Mol Sci. 2023 Aug 11, 24(16), 12709.|Int J Mol Sci. 2023 Jul 20, 24(14), 11692.|Int J Mol Sci. 2023 Mar 27.|Int J Mol Sci. 2023 May 12, 24(10), 8684.|Int J Neuropsychopharmacol. 2021 Jan 20;24(1):64-76.|Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):16.|iScience. 2023 May 30.|J Adv Res. 2023 Mar 28;S2090-1232(23)00090-5.|J Agric Food Chem. 2023 Aug 30;71(34):12645-12656.|J Agric Food Chem. 2023 Jan 15.|J Agric Food Chem. 2023 May 4.|J Am Heart Assoc. 2017 Sep 4;6(9). pii: e006347.|J Cell Biochem. 2019 Apr;120(4):5160-5168.|J Control Release. 2021 Jan 10;329:445-453.|J Endocrinol. 2023 Feb 16;256(3):e220335.|J Ethnopharmacol. 2023 Jun 11;116777.|J Ethnopharmacol. 2023 Mar 2;116304.|J Ethnopharmacol. 2023 Nov 27:117490.|J Funct Foods. 2023 Feb.|J Funct Foods. 2023 Jun, 105, 105582.|J Funct Foods. December 2020, 104274.|J Hypertens. 2023 Oct 10.|J Inflamm Res. 2023 Feb 27.|J Neuroimmunol. 2021, 577543.|J Neuroinflammation. 2018 Mar 24;15(1):95. |J Neuroinflammation. 2020 Jul 23;17(1):219.|J Nutr Biochem. 2023 Sep 2;109436.|Journal of Traditional and Complementary Medicine. 2023 Mar 29.|Kaohsiung J Med Sci. 2022 Nov 21.|Life Sci. 2020 Jul 15;253:117747.|Life Sci. 2021 Jan 15;265:118833.|Microbiol Immunol. 2023 Mar 18.|Mol Immunol. 2020 Jul;123:74-87.|Mol Med Rep. 2023 Sep 8.|Mol Neurobiol. 2023 Sep 13.|Molecules. 2022 May 4;27(9):2931.|Nat Commun. 2023 Feb 16;14(1):872.|Nat Commun. 2023 Jan 25;14(1):399.|Nat Immunol. 2022 Nov 28.|Nature. 2023 Nov 22.|Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 18.|Neurobiol Dis. 2018 Feb 23;114:24-30.|Neurobiol Dis. 2018 Sep;117:15-27.|Oncol Lett. 2020 Nov;20(5):170.|Oxid Med Cell Longev. 2023 Feb 17.|Pflugers Arch. 2020 Nov;472(11):1577-1586.|Pharmacol Res. 2020 Dec 19;164:105384.|Phytomedicine. 2023 Jul 25, 116, 154909.|Phytomedicine. 2023 Nov 8, 155193.|Platelets. 2023 Dec;34(1):2156492.|PLoS One. 2020 Oct 1;15(10):e0239659.|Redox Biol. 2020 Jul;34:101523.|Research Square Preprint. 2020 Nov.|Research Square Preprint. 2023 Aug 7.|Research Square Preprint. 2023 Jul 19.|Research Square Preprint. 2023 May 24.|Research Square Preprint. 2023 May 30.|Sci Total Environ. 2023 Jun 13;164787.|Science. 2020 Dec 4;370(6521):eaay2002.|Small. 2023 Oct 16:e2307448.|Toxins. 2023 May 29, 15(6), 366.
References
– [1]Zhai Y, et al. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules. 2018 Feb 27;23(3). pii: E522.|[2]Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55.
CAS Number
– 256373-96-3
Molecular Weight
– 426.46
Compound Purity
– 99.61
SMILES
– O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 30 mg/mL
Target
– NOD-like Receptor (NLR)
Isoform
– NLRP3
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
