MCC950 sodium
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MCC950 sodium

SKU T6887-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,792 CAD

Products Details

Product Description

– MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2, NLRC4 or NLRP1.

Web ID

– T6887

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C20H23N2O5S·Na

Citations

– 1. Luo F, Lin J.Effects of Propofol Anesthesia on Pyroptosis and the Nod-Like Receptor Protein 3/Caspase-1 Pathway in the Neonatal Rat Hippocampus.Indian Journal of Pharmaceutical Sciences.2023, 85(2): 338-343. 2. Wu X, Yi X, Zhao B, et al.The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function.Pharmacological Research.2023: 107016. 3. Li B, Li P, Wei L, et al.Discovery and Development of NLRP3 Inhibitors Targeting the LRR Domain to Disrupt NLRP3-NEK7 Interaction for the Treatment of Rheumatoid Arthritis.Journal of Medicinal Chemistry.2024

References

– Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55.

CAS Number

– 256373-96-3

Molecular Weight

– C20H23N2O5S·Na

Compound Purity

– 0.998

SMILES

– [Na+].CC(C)(O)c1coc(c1)S(=O)(=O)[N-]C(=O)Nc1c2CCCc2cc2CCCc12

Pathway

– NF-κB|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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