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MC-SN38
$400 – $3,400
Products Details
Product Description
– MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].
Web ID
– HY-136170
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H31N3O8
References
– [1]Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.|[2]Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.
CAS Number
– 1473403-87-0
Molecular Weight
– 585.60
Compound Purity
– 98.65
SMILES
– O=C(CCCCCN(C1=O)C(C=C1)=O)O[C@@](C(C=C(C2=NC3=CC=C4O)N5CC2=C(C3=C4)CC)=C6C5=O)(C(OC6)=O)CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 140 mg/mL (ultrasonic)
Target
– Drug-Linker Conjugates for ADC
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
