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Products Details
Product Description
– Mant-GTPγS, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS is a potent YdeH inhibitor[1][2][3].
Web ID
– HY-115748
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H23N6O14P3S
References
– [1]Andreas Gille, et al. 2′(3′)-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem. 2003 Apr 11;278(15):12672-9.|[2]Tomoharu Kanie, et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell. 2017 Jul 10;42(1):22-36.e12.|[3]Christian Spangler, et al. Interaction of the diguanylate cyclase YdeH of Escherichia coli with 2′,(3′)-substituted purine and pyrimidine nucleotides. J Pharmacol Exp Ther. 2011 Jan;336(1):234-41.
CAS Number
– 136749-24-1
Molecular Weight
– 672.39
SMILES
– O=C(C1=C(C=CC=C1)NC)O[C@H]2[C@](O[C@@H]([C@H]2O)COP(OP(OP(O)(S)=O)(O)=O)(O)=O)([H])N3C4=C(C(N=C(N4)N)=O)N=C3
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Adenylate Cyclase
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
