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Madecassic acid
$55 – $154
Products Details
Product Description
– Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].
Web ID
– HY-N0569
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C30H48O6
References
– [1]Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76(3):251-7.|[2]Xinming Yun, et al. Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells. Biochem Pharmacol. 2022.
CAS Number
– 18449-41-7
Molecular Weight
– 504.70
Compound Purity
– 99.23
SMILES
– C[C@@]([C@]([C@H](O)C1)([H])[C@]2(C)CO)(C[C@@H](O)[C@@H]2O)[C@](CC=C3[C@]4(CC[C@@](C(O)=O)(CC[C@H]5C)[C@@]3([H])[C@H]5C)C)([H])[C@]41C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– COX;Interleukin Related;NO Synthase;TNF Receptor
Isoform
– CD40;COX-2;IL-1;IL-6;iNOS
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Natural Products
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