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Products Details
Product Description
– Macbecin is a stable HSP90 inhibitor by binding to the ATP-binding site with an IC50 of 2 μM and a Kd of 0.24 μM. Macbecin exhibits antitumor and cytocidal activities[1].
Web ID
– HY-107578
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H42N2O8
References
– [1]Martin CJ, et al. Molecular characterization of macbecin as an Hsp90 inhibitor. J Med Chem. 2008 May 8;51(9):2853-7.
CAS Number
– 73341-72-7
Molecular Weight
– 558.66
SMILES
– O=C(C(NC(/C(C)=C/C=C/[C@H](C)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H](OC)[C@@H](OC)C[C@@H]1C)=O)=C2)C([C@]1([H])OC)=CC2=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HSP
Isoform
– HSP90
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
