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LY3372689
$390 – $3,200
Products Details
Product Description
– LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. LY3372689 can be used for tauopathies research, including Alzheimer’s disease[1][2].
Web ID
– HY-144681
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C16H22FN5O3S
References
– [1]Sergey Shcherbinin, et al. Brain target occupancy of LY3372689, an inhibitor of the O-GlcNAcase (OGA) enzyme: Translation from rat to human. Alzheimer’s & Dementia. 07 December 2020 .|[2]Nicolas Jacques Francois Dreyfus, et al. N-[4-fluoro-5-[[(2s,4s)-2-methyl-4-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]-1-piperidyl]methyl]thiazol-2-yl]acetamide as oga inhibitor. Patent WO2018140299A1.
CAS Number
– 2241514-56-5
Molecular Weight
– 383.44
Compound Purity
– 98.74
SMILES
– CC(NC1=NC(F)=C(S1)CN2[C@H](C[C@H](CC2)OCC3=NOC(C)=N3)C)=O
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Tau Protein
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
