Lumacaftor

$55$154

Products Details

Product Description

– Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.

Web ID

– HY-13262

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C24H18F2N2O5

References

– [1]Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86(1):42-51.|[2]Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8.

CAS Number

– 936727-05-8

Molecular Weight

– 452.41

Compound Purity

– 99.83

SMILES

– FC1(F)OC(C=C(C=C2)C3(CC3)C(NC4=NC(C5=CC=CC(C(O)=O)=C5)=C(C=C4)C)=O)=C2O1

Clinical Information

– Launched

Research Area

– Inflammation/Immunology

Solubility

– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– Autophagy;CFTR

Pathway

– Autophagy;Membrane Transporter/Ion Channel

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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