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Products Details
Product Description
– LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson’s disease[1].
Web ID
– HY-145318
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C25H29ClF2N6O2
References
– [1]Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.
CAS Number
– 2641054-60-4
Molecular Weight
– 518.99
SMILES
– FC1([C@@](N2C(C)=C(C=N2)NC3=NC4=C(C=C(C(C5CCN([C@]6([C@H](COC6)O)C)CC5)=C4)Cl)C=N3)([H])C1)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– LRRK2
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
