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Products Details
Product Description
– LRRK2-IN-10 (compound 34) is a potent, mutation-selective, and brain penetrant G2019S-LRRK2 kinase inhibitor with IC50s of 11 nM and 5.2 nM for G2019S-LRRK2 pS935 and G2019S-LRRK2 pS1292, respectively. LRRK2-IN-10 has the potential for Parkinson’s disease research[1].
Web ID
– HY-156167
Shipping
– Room temperature
Molecular Formula
– C20H15N5O
References
– [1]Albert W Garofalo, et al. Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.
CAS Number
– 2704562-80-9
Molecular Weight
– 341.37
SMILES
– N#CC1=CC(CC2)=C(C=C1)[C@H]2NC3=CC4=C(C=C3)NN=C4C5=CON=C5
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– LRRK2
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
