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Lotilaner
$250 – $1,700
Products Details
Product Description
– Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1].
Web ID
– HY-116564
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H14Cl3F6N3O3S
References
– [1]Lotilaner, et al. The novel isoxazoline ectoparasiticide lotilaner (Credelioâ„¢): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasit Vectors. 2017 Nov 1;10(1):530.
CAS Number
– 1369852-71-0
Molecular Weight
– 596.76
Compound Purity
– 99.84
SMILES
– O=C(NCC(NCC(F)(F)F)=O)C1=C(C=C(S1)C2=NO[C@](C3=CC(Cl)=C(C(Cl)=C3)Cl)(C2)C(F)(F)F)C
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : ≥ 100 mg/mL
Target
– GABA Receptor;Parasite
Pathway
– Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
