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Losartan
$50 – $132
Products Details
Product Description
– Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
Web ID
– HY-17512
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H23ClN6O
Citations
– Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592.|Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F941-F953.|Arch Biol Sci. 2021 Jun.|Biomolecules. 2022, 12(12), 1754.|Biomolecules. 2023 Apr 25, 13(5), 740.|Clin Sci. 2021 Mar 26;135(6):793-810.|Clin Transl Med. 2023 Mar;13(3):e1213.|FASEB J. 2018 Sep;32(9):5051-5062.|Friedrich-Alexander University Erlangen-Nuremberg. 2023 May 2.|Front Physiol. 2020 Sep 8;11:560170.|Gene. 2022 Jan 31;146239.|Int Immunopharmacol. 2023 Aug 4;123:110761.|Int J Mol Sci. 2023 Feb 3;24(3):2960.|Int J Nanomedicine. 2018 Nov 13;13:7409-7426. |J Pharmacol Sci. 2020 Sep;144(1):30-42.|Nefrologia. 2023 Sep 6.|Oncogene. 2023 Feb 23.|Oxid Med Cell Longev. 2022 Feb 18;2022:5044046.|Phytomedicine. 2022 Mar 21;100:154067.|Phytomedicine. 2023 Feb 4;112:154700.|Rep Biochem Mol Biol. 2021 Jul;10(2):314-326.|Reports of Biochemistry and Molecular Biology. 2021 Aug.|Research Square Print. September 13th, 2022.|Sci Rep. 2019 Dec 19;9(1):19450.|Cell Death Dis. 2020 May 22;11(5):390.|Chem Biol Interact. 2023 Jul 14;110636.|FASEB J. 2019 May;33(5):6254-6268.
References
– [1]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.|[2]Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.|[3]Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312(5770): p. 117-21.|[4]Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26(2): p. 233-40.|[5]Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126(1): p. 124-31.
CAS Number
– 114798-26-4
Molecular Weight
– 422.91
Compound Purity
– 99.67
SMILES
– OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology; Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Angiotensin Receptor
Isoform
– AT1 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
